Journal of Yeungnam Medical Science

Volume 10(2); December 1993

Original Articles

Review fo Autistic Disorder.: Jong Bum Lee, Hyung Bae Park; Yeungnam Univ J Med. 1993;10(2):263-286. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.263

1,475 View
4 Download

Abstract PDF: No abstract available.

Abdominoplasty.: Jung Hyun Seul, Jae Ho Jeong; Yeungnam Univ J Med. 1993;10(2):287-297. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.287

1,512 View
1 Download

Abstract PDF: No abstract available.

C-reactive protein inpregnancy and labor.: Jong Ho Kim, Byung Suk Kim, Jae Yul Lee, Young Gi Lee, Tae Hyung Lee, Seung Ho Lee; Yeungnam Univ J Med. 1993;10(2):298-305. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.298

1,469 View
1 Download

Abstract PDF: In order to evaluate the clinical usefulness of maternal serum C-reactive protein measurement in early detection of infectious morbidity at term laboring women, serum C-reactive protein levels were measured in 521 healthy pregnant women : 64 who were not in labor before term, 55 who were in labor before term, 71 who were not in labor at term and 331 who were in labor at term. The frequencies of elevated serum C-reactive protein level were compared in relation to the gestational weeks, the presence or absence of labor, the status of amniotic membranes and the degree of cervical dilation. The obtained results were as follows. 1. The frequencies of women with elevated serum C-reactive protein, 0.8 mg/dl or higher and 2.9 mg/dl or higher, in 521 health pregnant women were, 12 % and 4 %, respectively. 2. C-reactive pretein levels of 0.8 mg/dl or higher were more frequent in the group of women in labor than those not in labor(5. 93 %, vs, 13.73 %, p<0.05), but the frequencies of C-reactive protein level of 2.0 mg/dl or higher were not statistically different between both groups. The frequencies of C-reactive protein level of 0.8 mg/dl or higher and 2.0 mg/dl or higher were not statistically different between the groups before term and at term, intact and ruptured membranes, latent phase and active phase of labor, respectively. 3. Before term, C-reactive protein levels of 0.8 mg/dl or higher and 2.0 mg/dl or higher were more frequent in the group of women in labor than those not in labor(23.64 vs. 4.69, p<0.001 and 12.73% vs. 3.13%, p<0.05, respectively), but those statistical differences were not seen between both group at term. Above results and review of literature suggest that serum C-reactive protein level of 2.0 mg/dl or higher may be reliable in early detection of infectious morbidity at term laboring women as well as laboring women before term, and the presence of subclinical infection should be suspected in the laboring women before term with serum C-reactive protein level of 0.8 mg/dl or higher.

Meaning of anti hepatitis C virus antibody detection in patients treated with intravenous immunoglobulin: Myong Gyun Lee, Young Hwan Lee, Son Moon Shin, Jeong Ok Hah; Yeungnam Univ J Med. 1993;10(2):306-312. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.306

1,824 View
2 Download

Abstract PDF: To evaluate the meaning of anti-HCV detection in patients treated with IVIG, serum levels of aspartate aminotranstferase(AST), alanine aminotransterase(ALT), HCV Ab titer were measured after treatment with IVIG in 36 patients diagnised of Kawasaki disease or neonatal sepsis. Also polymerase chain reaction (PCR) for the detection of HCV was done in 8 patients with persistent HCV Ab positivity at 3 months after IVIG treatment. The results were as follows 1) HCV Ab was positive in all 36 patients at 1 week after IVIG treatment, but in only 8 cases it was positive at 3 months after IVIG treatment. 2) AST, ALT were elevated in 9 cases at 1 week after IVIG treatment, but they were normalized in all cases at 3 months after IVIG treatment. 3) PCR for the detection of HCV was done in 8 patients with persistent HCV Ab positivity at 3 months after IVIG treatment, but HCV was not isolated in any cases. These results suggested that detection of anti-HCV was merely transitory phenominon of HCV Ab transmission, did not show any evidence of HCV infection due to HCV transmission.

Fine structure and detoxification kinetics in kupffer cells after injection of endotoxin in rats.: Joon Hyuk Choi, Won Hee Choi, Tae Sook Lee; Yeungnam Univ J Med. 1993;10(2):313-337. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.313

1,639 View
8 Download

Abstract PDF: The aim of this study was to clarify the role of Kupffer cells in the mechanism of endotoxin-induced liver injury. The study on fine structure of Kupffer cells was performed after the injection of endotoxin. The endotoxin(Escherichia soli lipopolysaccharide 026: B6, 1.5mg/100 g of body weight) was intraperitoneally injected in Sprague-Dewley rats. Animals were sacrificed at 1/4, 1/2, 1, 2, 4, 8, 16, 24, 72 and 120 hours after the injection of endotoxin. Livers were extirpated and processed to be examined by light and electron microscopy. The results obtained were summerized as follows: Early changes observed in liver after endotoxin injection included the increased number and hypertrophy of Kupffer cells, infiltration of neutrophils and presence of fibrin thrombi within the sinusoids. The coritinuous increase of the Kupffer cells in number with hypertrophy, congestion and infiltration of inflammatory cells within the sinusoids were observed. Hepatocytes showed* fatty change and occasional necrosis. At 72 hours the congestion decreased. At 120 hours the number of Kupffer cells was increased, but the morphology of Kupffer cells became similar to that of the control group. The numbers and sizes of primary and secondary lysosomes and amount of euchromatin of Kupffer cells increased. Swellings and increase in number of mitochondria, Golgi complex, smooth endoplasmic reticulum, rough endoplasmic reticulum were evident. Microthrombi were present within the sinusoids. The swelling of rough endoplasmic reticulum and mitochondria, decrease of glycogen particles, fatty change, hypoxic vacuoles, pyknotic nuclei and occasional necrosis were observed in hepatocytes. At 72 hours the number of secondary lysosomes in Kupffer cells decreased. At 120 hours the morphology of Kupffer cells became similar to that of the control group. According to these results, it was postulated that the endotoxin was initially taken up by pinocytosis into Kupffer cells and degraded in secondary lysosomes of activated Kupffer cells. Kupffer cells may play an important role in the defense mechanism of liver during endotoxemia. The dysfunction of Kupffer cells and ischemia by sinusoidal microthrombi may cause liver injury.

A study of extraversion-introversion as a dimension of personality in schizophrenics.: Jung Hoon Lee; Yeungnam Univ J Med. 1993;10(2):338-344. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.338

1,776 View
2 Download
1 Crossref

Abstract PDF

The purpose of this study was to investigate the trait cortical arousal level, measured by extraversion-introversion, in schizophrenics. Subjects in this study were 231 (chronic schizophrenics= 78, acute schizophrenics= 62, and normal persons= 91). All subjects were asked to respond to extraversion-introversion subtest scale in the korean EPQ(Korean Version Eysenck Personality Questionnaire). Collected data were analyzed by using the. t-test and one-way analysis of variance. Results were as follows: 1) Trait cortical arousal level of chronic schizophrenics, which was measured by extraversion-introversion subtest scale in the Korean EPQ, was statistically higher than that. of. acute schizophrenics and normals. 2) Acute schizophrenics and normals were not significantly different in the trait cortical arousal level. However, the trait cortical arousal level of chronic schizophrenics was higher than that of acute schizophrenics. Therefore, it may state that the trait cortical arousal level of schizophrenics is getting higher when schizophrenic symptoms become more chronic.

Citations

Citations to this article as recorded by

A Study on Personality Traits and Cognitive Characteristics of the Sasang Constitution using Neuropsychological and Personality Tests
Munsu Kang, Gyung Yu, Lakhyung Kim
Journal of Oriental Neuropsychiatry.2015; 26(2): 131. CrossRef

Risk factors in relation to blood pressure in school children.: Dong Soo Lee, Kyeong Soo Lee, Pock Soo Kang; Yeungnam Univ J Med. 1993;10(2):345-359. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.345

1,581 View
2 Download

Abstract PDF: This study was conducted to identify the factors related to the blood pressure in school children. The study subjects were 144 boys and 140 girls aged 10 years old, 4th grade student of one elementary school in Taegu City. Blood pressure and 18 variables for 284 school children were measured in May 1992. A weight-for-height index, Rohrer index(weightlheighe) was calculated for each individual as a measure of obesity. Body fat percent, fat weight, and lean body mass were measured by impedance fat meter(Model SIF-891). Serum total cholesterol, higli-density lipoprotein, triglyceride, uric acid, total protein, and electrolyte were measured by automated clinical chemistry analyzer(Hitachi 4020). Low-density lipoprotein and atherogenic index were calculated by the equation. The variables assessed were sex, systolic blood pressure, diastolic blood pressure, Rohrer index, body fat percent, body fat weight, lean body mass, total cholesterol, high-density lipoprotein, low-density lipoprotein, uric acid, total protein, serum electrolyte and blood glucose. The mean systolic and diastolic blood pressures for boys were 104.1mmHg and 66.6mmHg and those for girls were 102.9mmHg and 67.5mmHg. Systolic blood pressure of boys was positively correlated with height, weight, Rohrer index, fat weight, lean body mass, and triglyceride. Systolic blood pressure of girls was positively correlated with height, weight, lean body mass, and uric acid. Diastolic blood pressure of boys was positively correlated with weight, Rohrer index, and lean body mass. Diastolic blood pressure of girls was positively correlated with height, weight, fat weight, and lean body mass and negatively with total serum protein. In multiple regression analysis for the systolic blood pressure, the significant independent variables were Rohrer index and serum sodium in boys, and serum uric acid, fat percent, and Rohrer index in girls. In multiple regression analysis of the diastolic blood pressure, the significant independent variables were Rohrer index in boys and total serum protein in girls. This study indicated that important factors influencing blood pressure in school children were Rohrer index, fat percent, serum sodium, uric acid, and total protein. Rohrer index was most important among these. It is recommended to enforce the nutritional education for diet control of obesity to prevent hypertention in children and to adopt healthy life-styles that promote good health and prevent development of cardiovascular risk factors.

Isolation of GTP binding from bovine brain.: Jung Hye Kim; Yeungnam Univ J Med. 1993;10(2):360-368. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.360

1,563 View
1 Download

Abstract PDF: GTP binding protein (G-protein) associated with membrane and involved in signal transduction was isolated from bovine brain, and molecular weight of G protein was observed. As the results, cell membranes were homogenized from bovine brain tissues and proteins of membrane were gained using 1% cholate, and progressed the chromatography. The purification process was performed by step, DEAE-Sephacel, Ulttrogel AcA 34 and heptylamine-Sepharose column chromatography. The chromatographic fractions were confirmed by GTP binding assay and SDS-polyacrylamide gel electrophoresis. Molecular weight of Goa was revealed 39,000 dalton and GR 36,000 dalton. One more step of heptylamine-Sepharose was enforced to purify the GTP binding protein. Finally I gained the GTP binding protein isolated subtype of Goalpha and Gbeta.

A study of bone mineral density of lumbar spine by dual energy x-ray absorptiometry (DEXA) in children.: Chur Woo You, Son Moon Shin, Yong Hoon Park, Son Yong Kim; Yeungnam Univ J Med. 1993;10(2):369-379. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.369

2,044 View
3 Download

Abstract PDF: The bone mineral density(BMD) of the lumbar spine (L2L4) was measured by using dual energy x-ray absorptiometry(Norland M6 DEXA) in 80 children aged between 2months and 15years (group I:2monthlyears, group 2: 1year5years, group3:6years10years, group4*: 11years15years). The correlation coefficient of BMD with age, body weight, height and Tanner stage were 0.696, 0.693, 0.717 and 0.636 respectively. There were sigificant difference. in BMD(g/cm2) between-group 1(BMD : 0.335 0.175) and group 2(BMD : 0.627 0.200), and group 3(BMD : 0.714 0.189) and group.4(BMD : 0. 8730.163) (P<0.05). There was no significant difference of BMD between boys and girls(P<0.05). BMD also increased significantly with development of Tanner stages(Tanner stage 1 : 0.547 0.234, Tanner stage 2 : 0.783 0.136, Tanner stage 3 : 0.998 0.080) (P<0.05). These data indicate that the BMD was correlated with age, body weight, height and Tanner stage significantly and BMD increased significantly during growth spurt occured in 1 to 4years of age and puberty.

Conservative surgery and definitive radiotherapy in early breast cancer: Sei One Shin, Jung Sook Hong, Myung Se Kim, Young Do Lee, Sung Kyu Kim, Soo Jung Lee; Yeungnam Univ J Med. 1993;10(2):380-387. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.380

1,556 View
3 Download

Abstract PDF: Local excision and axillary dissection followed by radiation therapy to the breast has been shown to achieve equivalent local control and survival as mastectomy in an prospective randomized trials. We analyzed 28 cases of early breast cancer in order to evaluate the therapeutic effects of conservative f surgery and definitive radiotherapy in the management of early breast cancer as possible alternative of simple mastectomy, retrospectively. Obtained results were as follows 1. Treatment related acute side reactions are more prominant in the case of chemoradiotherapy group than radiotherapy alone group. 2. There were no cases of primary, regional or systemic failures on the last follow up examination. 3. Cosmetic results after treatment were satisfactory in 26 cases out of 28 cases on the last follow up examination. 4. There were no demonstrable differences of tumor control and cosmetic results between the treatment groups. Although, these results suggested that definitive radiotherapy after local excision would be a possible and desirable alternative instead of total mastectomy in the management of early breast cancers, analyzed cases were too small and follow up period was too short to evaluate the therapeutic effect of primary radiotherapy after local excision, exactly.

Treatment of tibial fractures by interlocking intramedullary nailing.: Kwang Yeoung Jung, Dong Chul Lee, Jae Sung Suh, Se Dong Kim; Yeungnam Univ J Med. 1993;10(2):388-399. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.388

1,593 View
4 Download

Abstract PDF: The adequate treatment of tibia fracture is one of the most difficult due to severe commiuntion, open wound, delayed union, angulation deformity and infection. We treated 38 fractures of the tibia by Interlocking intramedullary nail from Feb. 1983 to Mar. 1993. 35 cases of the tibia fracture were fresh, 13 cases of fracture were open. The other 3 cases were delayed union and nonunion. The Mean follow-up was 14.0 months. The results were as followings. 1. Of the 38 fractures, 37 fractures united and the mean union time was 18.7 weeks. 2. Interlocking intramedullary nail could be used to the majority of fractures of the proximal & distal tibia shaft. fractures. 3. The Im erlocking nail had rigid rotational stability and was appropriate for the treatment in severe unstable fractures, commninution and open-with bone loss. 4. Delayed union or nonunion was a good indication for intramedullary nailling. 5. The major-complication were valgus deformity of 2 cases, varus deformity of 1 case, 1 case deep infection. 6. Interlocking intramedullary nailing provided rigid fixation of . fracture and then made early joint motion exercise and ambulation.

Percutaneous K-wire fixation of supracondylar fracture of humerus in children.: Duk Seop Shin, Jong Chul Ahn, Se Dong Kim, Dong Woo Lee; Yeungnam Univ J Med. 1993;10(2):400-408. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.400

1,562 View
5 Download

Abstract PDF: During the period from March 1990 to November 1993, 22 children with diplaced supracondylar fracture of humerus were treated by closed reduction and percutaneous K-wire fixation at department of Orthopaedic surgery in Yeungnam University. All fracture were treated with closed reduction under the general anesthesia and percutaneous pinning. After the fracture was internally fixed, intraoperative anteroposterior reontgenograms of each distal humerus were compared. Only anatomical reduction ensured good result,, because the main cause of late cubitus varus was medial tilting of distal fragment. We could follow up 10 patients more than one year. By Flynn's criteria, satisfactory result were obtained in 9 of the 10. Unsatisfactory one had a limitation in flexion of elbow joint, but had no problem in cosmetic feature. In short term follow up of 7 patients, 5 patients had a satisfactory result, too. There were no neurovascular complication and hospitalization was shortened to 11.4 days. Closed reduction and percutaneous pinning provided stabillity, vascular safty, simplified management, reduced hospital stay. This is safe and reliable technique for obtaining and maintaining an exellent reduction.

Comparison study of AAS and ISE method in the lithium analysis of serum and urine.: Soo In Lee, Chae Hoon Lee, Kyung Dong Kim, Chung Sook Kim; Yeungnam Univ J Med. 1993;10(2):409-416. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.409

2,324 View
22 Download

Abstract PDF: In the method for lithium (Li) analysis, flame emission photometry and atomic absorption spectrophotometry (AAS) have been used most frequently. In addition, lithium can be analyzed by ion-selective electrode (ISE) or fluorscence polarization immunoassay. We evaluated the comparison between AAS method based on the principle of absorption of light at 670.8 nm by Li and ISE method based on the principle of voliage difference generated by Li in contact with lithium ionophore. We compared with those obtained by AAS (AA/AE Spectrophotometer 551, Instrumentation Laboratory Co.) and ISE (SYNCHRON EL-ISE, Beckman Co.) in the serum and urine of 6 pati,,:nts- and evaluated time-related changes of serum lithium concentration after dosing in both methods. The results are summarized-as follows: 1. In within-run precision study for lithium concentration, coefficient variations (CVs, %) ranged from 1.34 to 2.17 for AAS and from 0.34 to 0.85 for ISE method. In between-run precision study for lithium concentration, CVs ranged from 1.23 to 1.72 for AAS and from 0.61 to 1.38 for ISE method. 2. The correlation study between AAS and ISE method resulted in Y= 0.946X+ 0.137 (N = 32, r= 0. 933, X= AAS, Y= ISE) for serum lithium and Y= 1. 092X+ 0. 977 (N= 28, r= 0.943, X= AAS, Y= ISE) for urine lithium. 3. Time-related changes of serum lithium concentration in both AAS and ISE method resulted in peak serum levels about 2 hours after dosing and then rapidly decreased after the peak serum level and finally arrived at nearly initial levels about 9 hours after dosing. 4. The reference range of serum lithium was found as undetectable level for both AAS and ISE method and the reference range of urine lithium to the urine creatinine was 0 0.00014 mmol/mg(mean 0.00002 mmol/mg) for AAS method.

Computed tomographic findings of malignant ovarian germ cell tumors: Woo Mok Byun, Kil Ho Cho, Bok Hwan Park; Yeungnam Univ J Med. 1993;10(2):417-422. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.417

1,398 View
4 Download

Abstract PDF: Diagnosis of malignant germ cell tumors of the ovary is usually difficult because many ovarian neoplasms have similar clinical and radiologic manifestations. We reviewed retrospectively 12 cases of ovarian malignant germ cell tumor and evaluated with respect to size, mass characteristics on computed tomography for differential diagnosis. Endodermal sinus tumors were mainly cystic mass with some solid component and septations. Immature teratomas showed typical manifestations, such as fatty tissue, calcifications, cysts, and irregular shaped soft tissue densities. Dysgerminoma was mainly solid mass without cystic component, and mixed germ cell tumor showed nonspecific manifestations. All cases were relatively large in size, and young in age. In conclusion, CT findings of malignant germ cell tumors are helpful in differential diagnosis

The risk factors of recurrent ischemic stroke: Cheol Jung, Wook Nyneon Kim, Min Jeung Kim, Soek Mum Choi, Kyung Yoon Eur, Mee Young Park, Jeng Sang Hah, Yeung Ju Byun; Yeungnam Univ J Med. 1993;10(2):423-431. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.423

1,927 View
12 Download
2 Crossref

Abstract PDF

To evaluate the risk factors which are related to recurrence of ischemic stroke, we selected subjects who were admitted to YNUH due to recurrent stroke and compared their risk factors with non-recurred group- who suffered from single ischemic stroke. In the subjects, 55 of them are men and 22 were women and in the non-recurred groups, 84 of them were men and 40 were women, Subject's age ranged from 29 to 86 years (Mean 62.5years), and non-recurred group's age ranged from 27 to 90 years (Mean 60.7years), Peak incidence of ischemic stroke is in the 7th decade in both groups. Age and sex are not statistically significant for recurrence of ischemic stroke. The patient's history of diabetes mellitus, myocardial infarction, atrial fibrillation, transient attack and type or site of ischemic stroke had no significant effect statistically on the recurrent ischemic stroke. However, when the patient had previous history of hypertension or systolic blood pressure more than 160 mmHg and diastolic more than 95mmHg, there was substantial difference (P<0.05) between the two group in the recurrence of ischemic stroke. According to the above results, hypertension is most likely significant risk factor of the recurrence of ischemic stroke within 2 yers after initial one. Therefore, adequate treatment of the hypertension is important for the prevention of ischemic stroke. Further study is required for searching other risk factors.

Citations

Citations to this article as recorded by

Hemiplegic Experience after Stroke among Middle Aged Man
Soo-Yong Oh, Jeong-Seop Lee
Journal of the Korea Academia-Industrial cooperation Society.2016; 17(5): 582. CrossRef
Knowledge, health‐promoting behaviors, and biological risks of recurrent stroke among stroke patients in Korea
Hei Ryun Lee, Ok Kyung Ham, Young Whee Lee, Insook Cho, Hyun Soo Oh, Joung‐Ho Rha
Japan Journal of Nursing Science.2014; 11(2): 112. CrossRef

Membrane protein alterations associated with anticancer drug resistance in mouse lymphoblastic leukemia L1210 cells: Seong Yong Kim, Sung Kweon Son, Jae Ryong Kim, Jung Hye Kim; Yeungnam Univ J Med. 1993;10(2):432-444. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.432

1,726 View
1 Download
1 Crossref

Abstract PDF

Multidrug resistance (MDR) phenotype is frequently observed in animal and human cancer cell lines selected for in vitro resistance to a single chemotherapeutic agent. It is characterized by the diminished j drug accumulation and is related to the drug efflux mechanism in resistant cells. In the present study, adriamycin resistant cells (L1210-AdR6: 10-6M adriamycin, -AdR5: 10-5M) and vincristine resistant cells (L1210-VcR7: 10-7M vincristine, -VcR6: 10-6M) were produced from mouse lymphoblastic leukemia cell line L1210. Growth profiles of survived cells were observed for 5 days with MTT (thiazolyl blue) assay and resistance was compared with IC50 (drug concentration of 50% survival reduction in absorbance). Resistant cells proliferated more slowly than sensitive cell. Doubling times were 29.7hr in L1210, 68.7 hr in L1210-AdR5 and 58.2 hr in -VcR6. MDRs expressed as resistance factor were as follows, L1210-AdR5 was 76.4 times for vincristine, L1210-VcR6 was 96.4 times for adriamycin. The cell membrane proteins with three different M.W. were recognized to be related resistance, 220, 158, and 88 Kd in L1210-AdR5, 158, 140 and 88 Kd in L1210-VcR6 by SDS-PAG electrophoresis. Cell surface membrane proteins were identified by radio-iodination and autoradiogram. Their molecular weights were 158, 72.8, and 42.4 Kd in L1210-VcR6.

Citations

Citations to this article as recorded by

Suppression of P-glycoprotein expression by antipsychotics trifluoperazine in adriamycin-resistant L1210 mouse leukemia cells
Soon Young Shin, Byeong Hyeok Choi, Jae-Ryong Kim, Jung-Hye Kim, Young Han Lee
European Journal of Pharmaceutical Sciences.2006; 28(4): 300. CrossRef

Postoperative analgesic effect of intraarticular bupivacaine or morphine after arthroscopic knee surgery.: Sae Yeon Kim; Yeungnam Univ J Med. 1993;10(2):445-450. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.445

1,391 View
1 Download

Abstract PDF: Recent studies have shown that opiods can produce potent antinociceptive effects by interacting with opioid receptors in peripheral tissues. This study sougt to compare the effects of morphine with those of-bupivacaine administered intraarticularly upon pain after arthroscopic knee surgery. In a ramdomized manner, 60 healthy patients received either morphine(3 mg in 20 ml NaCl : n=20), bupivacaine(20 ml, 0.25% : n=20) intraarticularly at the completion of surgery, and others were not administered (n = 20) under general anesthesia after 1, 2, 4, 6, 12 and 24h of postoperative day, pain was assessed by a visual analogue pain scalps, time to first analgesic use were recorded. Pain scores were signicantly greater in the morphine group than two groups at 11. From 4th until the end of the study period, pain scores were significantly greater in the bupivaca.ne group than in the other two group. Anagesic requirements were significantly greater in the morphine group than two groups at 1h but were significantly greater in the bupivacaine group than in the other groups throughout the remainder of the study period. The results suggest that intraarticular morphine produces an analgesic effect of delayed onset but of remarkably long duration.

The effect of lidocaine dose and pretreated diazepam on cardiovascular system and plasma concentration of lidocaine in dogs ansthetized with halothane-nitrous oxide: Kyeong Sook Lee, Sae Yeon Kim, Dae Pal Park, Jin Mo Kim, Chung Gil Chung; Yeungnam Univ J Med. 1993;10(2):451-474. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.451

1,710 View
6 Download

Abstract PDF: Lidocaine if frequently administered as a component of an anesthetic: for local or regional nerve blocks, to mitigate the autonomic response to laryngoscopy and tracheal intubation, to suppress the cough reflex, and for antiarrhythmic therapy. Diazepam decrease the potential central nervous system (CNS) toxicity of local anesthetic agents but -may modify the stimulant action of lidocaine in addition to their own cardiovascular depressant. The potential cardiovascular toxicity of local anesthetics may be enhanced by the concomitant administration of diazepam. This study was designed to investigate the effects of lidocaine dose and pretreated diazepam to cardiovascular system and plasma concentration of lidocaine. Lidocaine in 100 mcg/kg/min, 200 mcg/kg/min, and 300 mcg/kg/min was given by sequential infusion to dogs anesthetized with halothane-nitrous oxide (Group I). And in group II, after diazepam pretreatment, lidocaine was infused by same way when lidocaine was administered in 100 mcg/kg/min, the low plasma levels (3.97+/-0.22-4.48+/-0.36 mcg/ml) caused a little reduction in cardiovascular hemodynamics. As administered in 200 mcg/kg/min, 300 mcg/kg/min, the higher plasma levels (7.50+/-0.66-11.83+/-0.59 mcg/ml) reduced mean arterial pressure (MAP), cardiac index (CI), stroke index (SI), left ventricular stroke work index (LVSWI), and right ventricular stroke work index (PVSWI) and increased pulmonary artery wedge pressure (PAWP), central venous pressure (CVP), systemic vascular resistance index (SVRI), but was associated with little changes of heart rate (HR), mean pulmonary artery pressure (MPAP), and pulmonary vascular resistance index (PVM). When lidocaine with pretreated diazepam was administered in 100 mcg/kg/min, the low plasma level, the lower level than when only lidocaine administered reduced MAP, but was not changed other cardiovascular hemodynamics. While lidocaine was infused in 200 mcg/kg/min, 300 mcg/kg/min in dogs pretreated diazepam, the higher plasma level (7.64+/-0.79-13.79+/-0.82 mcg/ml) was maintained and was associated with reduced CI, SI, LVSWI and increased PAWP, CVP, SVRI but was a little changes of HR, MPAP, PVRI. After CaCl2 administration, CI, SI, SVRI, LVSWI was recovered but PAWP, UP was rather increased than recovered. The foregoing results demonstrate that pretreated diazepam imposes no additional burden on cardiovascular system when an infusion of large dose of lidocaine is given to dogs anesthetized with halothane and nitrous oxide. But caution may be advised if the addition of lidocaine is indicated in subjects who have impaired autonomic nervous system and who are in hypercarbic, hypoxic, or acidotic states.

Effects of selective obstruction of intracranial venous sinuses on systemic arterial pressure, cerebral perfusion pressure, intracranial pressure and intrasinal pressure in cats: Eun Sig Doh, Soo Ho Cho; Yeungnam Univ J Med. 1993;10(2):475-484. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.475

1,351 View
2 Download

Abstract PDF: In order to evaluate the safe ligation time and sites of dural venous sinuses during neurosurgical operation, systemic arterial pressure (SAP), cerebral perfusion pressure (CPP), intracranial pressure (ICP) and intraspinal pressure (ISP) were measured in cats through neuromonitor before and after obstruction of anterior 1/3, middle 1/3, posterior 1/3 of the superior sagittal sinus and the results were as follows. There were no significant increases of pressures after obstruction of anterior 1/3 of the superior sagittal sinus. In the obstructed middle 1/3 of the superior sagittal sinus group, significant increases were seen the m-SAP within 2, 4 and 6 minutes, the m-ICP within 2-7 minutes, the m-ISP within 14 minutes after obstruction. In the -obstructed posterior 1/3 of the superior sagittal sinus group, there were significant increases of m-SAP within 2, 4 and 6 minutes, the m-ICP within 27 minutes, the m-ISP within 13 minutes. In the obstructed Torcular Herophili group, there were significant increases of the m-SAP within 1-2 and 4-7 minutes, the m-ICP within 36 minutes and the m-ISP within 1-7 minutes and less significant decreases of the m-CPP within 5-7 minutes after obstruction. In the obstructed right transverse sinus group, significant increases of the m-ICP and the m-ISP were seen within 1-7 minutes after obstruction. There were no remarkable changes in the obstructed left transverse sinus group.

Histopathologic findings of necrotizing lymphadenitis.: Young Ran Shim, Hae Joo Nam; Yeungnam Univ J Med. 1993;10(2):485-492. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.485

1,407 View
12 Download

Abstract PDF: Necrotizing lymphadenitis was first recognised as a self-limiting lymphadenitis by Japanese workers in 1972. It is a distinct clinicopathologic entity, but can be mistaken as malignant lymphoma. We have studied clinicopathologic features in 15 cases of necrotizing lymphadenitis. This disease occurs predominantly in young adult. Male-female ratio is 2 : 1. The commonest presentation is lateral cervical lymphadenopathy. Pain, tenderness, and fever can be seen. Biopsy of the lymph nodes from all patients demonstrates the characteristic histologic features : multifocal, relatively circumscribed nodules in the cortex and/or paracortex, consisting of a mixture of activated large lymphoid cells, histiocytes and Small lymphocytes. Numerous karyorrhetic debris are present. Neutrophils and plasma cells are strikingly absent.

Clinical experiences on the treatment of congenital cutis aplasia and craniosynostosis.: Kyung Ho Lee; Yeungnam Univ J Med. 1993;10(2):493-505. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.493

1,521 View
1 Download

Abstract PDF: The congenital cutis aplasia mainly occurs in head, sometimes involving the skull and dura mater. It's cause and the rate of falling ill are not known yet, it is the disease that rate of death is high by the infection, such as, the injured vascular hemorrhange of meningitis. Craniosynostosis is the disease the appears the skull as well as the facial deformity with growing, has from the developmental difficiency, visual distibance, motor disturbance, convulsion to the neurologic impairment of mental retardation, and accompanies the each characteristic deformity follwing the suture fused. Satsifactory results was achieved by local flap surgery and conservative treatment on the infant, diagnosed as the congenital cutis aplasia. case 1 Also successful treatment experiences of craniosynostosis(oxycephaly, brachycephaly, trigonocephaly, cloverleaf deformity) through the frontal bone advancement and the barrel stave asteotomy, were reviewed & pursues and investigates the intracranial volume of before and after of surgery, and then reports with the literature investigation.

Treatment of PDA in premature newborns with mefenamic acid.: Jae Joon Lee, Young Hwan Lee, Son Moon Shin; Yeungnam Univ J Med. 1993;10(2):506-511. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.506

1,919 View
12 Download
1 Crossref

Abstract PDF

This study was conducted to examine the effect of mefenamic acid for treatment of PDA in premature newborns. Ductus arteriosus is reopened by locally produced prostaglandin E2 in a premature newborn during hypoxia. Mefenamic acid is one of non-steroidal antiinflammatory drugs acting by inhibition of cyclo-oxygenase in the prostaglandin synthesis pathway. For three premature newborns with PDA, we administered mefenamic acid and evaluated them with echocardiography to study the effect of mefenmic acid for closure of PDA. In all three babies, ductus arteriosus was closed successfully. We feel that mefenamic acid is safe and effective medication for treatment of PDA in premature newborns, but further-study need to be conducted with larger numbers of cases to confirm this effect.

Citations

Citations to this article as recorded by

Efficacy of oral mefenamic acid versus paracetamol as a prophylactic analgesic for needle pain in children receiving vaccination: a three-arm, parallel, triple-blind, placebo-controlled MAP VaC randomized controlled trial
Rachna Pasi, Thirunavukkarasu Arun Babu, Vinoth Kumar Kallidoss
Therapeutic Advances in Vaccines and Immunotherapy.2023;[Epub] CrossRef

A case of idiopathic thrombocytopenic purpura in pregnancy.: Mi Sook Kim, Ho Joon Hwangbo, Young Gi Lee, Yoon Kee Park, Sung Ho Lee; Yeungnam Univ J Med. 1993;10(2):512-517. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.512

1,535 View
2 Download

Abstract PDF: Idiopathic thrombocytopenic purpura is an uncommon illness but most common form of thrombocytopema in pregnancy. Corticosteroids, splenectomy, immunosuppressive drugs, and immunoglobulin therapy have been recommended for manaaement. The optimal method of delivery is controversial. We have experienced a case of idiopathic thrombocytopenic purpura diagnosed previously and managed with corticosteroid and vincrstine, which was followed by pregnancy, vaginal delivery and postpiirtum splenectomy.

Hyperinfection of strongyloides stercoralis.: Kyeong Cheol Shin, Jun Ha Chun, Chan Weon Park, Choong Ki Lee, Hyun Woo Lee; Yeungnam Univ J Med. 1993;10(2):518-524. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.518

1,543 View
1 Download

Abstract PDF: Strongylodiasis is universal in distribution but is most abundant in countries with a tropical climate. Although infestation by Strongyloides stercoralis is usually limited to the intestines, dessemination of this helminth in debilitated host can be lead to death with various clinical disorders. characterized by profound malabsorption, diarrhea, electrolyte imbalance, gram negative or opportunistic fungal sepsis, coma and death. Cell-mediated immunity contributing significantly to the control of helminthic infections, may be suppressed by carcinoma, immunosuppressive chemotherapy and use of corticosteroids. Diagnosis of Strongyloidiasis is achieved by an examination of samples of feces, duodenal aspirates and sputum of patients for Strongyloides stercoralis. Treatment of strongyloidiasis is twofold : correction of the immunosuppressive state by withdrawal of immunosuppressive drug, if possible, and vigorous treatment with thiabendazole. Testing for strongyloidiasis is especially recommanded before treating a patients should be monitored for infection by Strongyloides stercoralis and other opportunistic infection. We are reporting a case patient with Strongyloides stercoralis hyperinfection and pulmonary tuberculosis who had been. used corticosteroid for persisting polyarthritis.

Two cases report of bronchial carcinoid tumors.: Kyo Won Choi, Jeong Ill Suh, Sung Suk Kim, Jin Hong Chung, Kwan Ho Lee, Hyun Woo Lee, Dong Hyup Lee, Jung Cheul Lee, Sung Sae Han; Yeungnam Univ J Med. 1993;10(2):525-536. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.525

1,568 View
3 Download

Abstract PDF: Bronchial carcinoid tumor was a low grade malignant and it was regarded as predictable clinical course and good survivality after surgical resection. But despite of its low grade malignant potentiality, bronchial carcinoid tumor was clearly capable of metastasizing and causing death. We present 2 cases of bronchial carcinoid tumors. One of them was typical carcinoid tumor in 44 year-old female and another was atypical carcinoid tumor in 53 year-old male patient. Currative therapeutic procedure was performed by lobectomy and wedge resection.

Emphysematous pyelonephritis : a case report and review of the literature.: Hyun Dae Yoon, Kyu Chang Won, Chan Woo Lee, In Ho Jo, Hyung Woo Lee, Kyung Woo Yoon, Heun Ju Lee, Hyun Woo Lee, Cheol Kyu Cho; Yeungnam Univ J Med. 1993;10(2):537-543. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.537

1,677 View
1 Download

Abstract PDF: Emphysematous pyelonephritis is a necrotizing renal infections characterized by intrarenal and occasional perirenal gas production. Although uncommon (89 cases in the literature), it occurs almost exclusively in diabetic patients (87% of the cases). Prompt and aggressive management is required to sahage these patients. We describe a recent case of a diabetic woman with emphysematous pyelonephritis due to E. Coll, successfully managed with unilateral nephrectomy.

A case of atrophy of bilateral frontal lobe which showed negative symptoms of schizophrenia.: Tae Yong Rho, Jin Sung Kim; Yeungnam Univ J Med. 1993;10(2):544-549. Published online December 31, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.2.544

1,462 View
3 Download

Abstract PDF: The authors have experienced a case of organic mental disorder with bilateral frontal lobe atrophy in. a 36-year-old man. He showed negative symptoms of schizophrenia such as anhedonia, social withdrawal, flat affect, poverty of thought.

First
Prev
Page of 1
Next
Last

Previous issues