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JYMS : Journal of Yeungnam Medical Science

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Yong-Woon Kim 3 Articles
Beneficial effects of intermittent fasting: a narrative review
Dae-Kyu Song, Yong-Woon Kim
J Yeungnam Med Sci. 2023;40(1):4-11.   Published online April 4, 2022
DOI: https://doi.org/10.12701/jyms.2022.00010
  • 6,626 View
  • 356 Download
  • 2 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily applicable dietary intervention for caloric restriction. Moreover, intermittent fasting has beneficial effects equivalent to those of caloric restriction in terms of body weight control, improvements in glucose homeostasis and lipid profiles, and anti-inflammatory effects. In this review, the beneficial effects of intermittent fasting are discussed.

Citations

Citations to this article as recorded by  
  • Intermittent fasting and longevity: From animal models to implication for humans
    Olha Strilbytska, Svitlana Klishch, Kenneth B. Storey, Alexander Koliada, Oleh Lushchak
    Ageing Research Reviews.2024; 96: 102274.     CrossRef
  • Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females
    Purwo Sri Rejeki, Adi Pranoto, Deandra Maharani Widiatmaja, Dita Mega Utami, Nabilah Izzatunnisa, Sugiharto, Ronny Lesmana, Shariff Halim
    Sports.2024; 12(5): 116.     CrossRef
  • Effect of Intermittent Fasting Interventions for Treatment of Overweight and Obesity in Adults – A Systematic Review
    Teena Lal, S. J. Ajeet Arulkumar, S. Roopa
    Acta Medica International.2024; 11(1): 7.     CrossRef
  • Intermittent fasting influences immunity and metabolism
    Daniel M. Marko, Meghan O. Conn, Jonathan D. Schertzer
    Trends in Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling
    Wenzhen Yin, Lijun Sun, Yuan Liang, Chao Luo, Tiange Feng, Yunhua Zhang, Weizhen Zhang, Yue Yin
    The FASEB Journal.2023;[Epub]     CrossRef
  • Time-Restricted Feeding and Intermittent Fasting as Preventive Therapeutics: A Systematic Review of the Literature
    Arturo P Jaramillo, Javier Castells, Sabina Ibrahimli, Luisa Jaramillo, Rebeca R Briones Andriuoli, Denisse Moncada, Jhoanny C Revilla
    Cureus.2023;[Epub]     CrossRef
Effect of Paraxanthine on Body Fat Reduction and Insulin Sensitivity in Monosodiun Glutamate-Obese Rats
Jae-Kyung Song, So-Young Park, Jong-Yeon Kim, Hee-Sun Kim, Yong-Woon Kim
Yeungnam Univ J Med. 2007;24(2 Suppl):S481-492.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S481
  • 1,522 View
  • 7 Download
  • 1 Crossref
AbstractAbstract PDF
Purpose:To evaluate the effects of body fat reduction on insulin sensitivity, it was measured the glucose disappearance rate, glucose infusion rate, and hepatic glucose production rate after paraxanthine (1,7-dimethylxanthine, metabolite of caffeine) treatment in monosodium -L-glutamate (MSG)-obese rats. Materials and Methods:Obesity was induced by neonatal (2, 4, 6, 8, 10 days) injection of MSG(4 g/kg, subcutaneously) for 15 weeks. MSG-obese rats showed severe fat deposition in subcutaneous and intraabdominal cavity, shortened body length, normoglycemia, hyperinsulinemia, and high FFA level. Insulin sensitivity was assessed with hyperinsulinemic euglycemic clamp technique under anesthesia with pentothal sodium. Plasma insulin concentration was clamped at 100 μU/ml by continuous insulin infusion (1.5 mU/kg/min). At steady state, the glucose disappearance rate and glucose infusion rate were decreased and the hepatic glucose production rate was increased in the MSG-obese rats compared to the normal rats.
Results
:At 15 weeks of age, paraxanthine (15 mg/kg) was administered with ephedrine (60 mg/kg) via per oral for 15 consecutive days. Body fat mass of the paraxanthine treated rats was decreased about 29.6% in the MSG-obese and 6.3% in the normal rats compared with the control rats during 15 days. In the paraxanthine treated MSG-obese rats, the fasting insulin level was significantly (p<0.05) decreased and the glucose infusion rate was significantly (p<0.05) increased compared to that of the MSG-control rats, however the glucose disappearance rate showed increasing tendency and the hepatic glucose production rate showed decreasing tendency compared to that of the MSG-control rats.
Conclusion
:These results suggest that paraxanthine exerts an anti-obesity effect and improve insulin sensitivity in rats with MSG-induced obesity.

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  • Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice
    Jing Yu, Hao Sun, Yang Yang, Yaping Yan
    International Journal of Molecular Sciences.2022; 23(22): 13853.     CrossRef
Effect of Saturated and Unsaturated Fatty Acid on Ob Gene and Fatty Acid Synthase Gene Expression in 3T3-L1 Adipocyte
Jeong-Kyu Chi, So-Young Park, Jong-Yeon Kim, Hee-Sun Kim, Yong-Woon Kim
Yeungnam Univ J Med. 2007;24(2 Suppl):S493-504.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S493
  • 1,250 View
  • 13 Download
AbstractAbstract PDF
Purpose:The ob gene, specifically expressed in adipocyte, encodes leptin, a hormone that induces satiety and increases energy expenditure. In this study, effects of saturated fatty acid and polyunsaturated fatty acid on ob gene expression were investigated by quantitative competitive RT-PCR in a mouse cell line (3T3-L1) which can be induced to differentiate into adipocytes. In addition to ob gene, expression of the fatty acid synthase gene as a marker of lipogenesis was measured simultaneously. Materials and Methods:The 3T3-L1 fibroblast cell were cultured in the Dulbecco’s modified Eagle medium with 10% fetal bovine serum. The differentiation of 3T3-L1 fibroblast to adipocyte was induced by the treatment of 250 nM dexamethasone and 0.5mM 1-methyl-3 -isobutylxanthine. At 10∼14 days after induction, 3T3-L1 cells were fully differentiated and had had lipid droplets in the cytoplasm. At that time, 3T3-L1 adipocytes were cultured for 12 hours in the fatty acids contained medium and were harvested for RNA extraction. Palmitate as a saturated fatty acid and docosahexaenoic acid (DHA) as a polyunsaturated fatty acid were used in this experiment and treated concentration was 600 μMol.
Results
:After conversion to adipocytes, glycerol-3 phosphate dehydrogenase activity was increased and leptin mRNA was expressed. Ob gene expressions of differentiated adipocytes were suppressed by palmitate treatment, however, there was no significant change in DHA treated adipocyte. Fatty acid synthase gene expressions, on the other hand, were suppressed by DHA treatment and not changed by palmitate treatment.
Conclusion
:These results suggested that polyunsaturated fatty acid inhibited lipogenic process and saturated fatty acid inhibited lipolytic process at cultured adipose cell level.

JYMS : Journal of Yeungnam Medical Science