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JYMS : Journal of Yeungnam Medical Science

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Won Jong Park 9 Articles
Late complication of the Nuss procedure: recurrent cardiac tamponade
Won Jong Park, Jang Won Son, Kyu Hwan Park, You Min Kim, Jong Ho Nam, Kang Un Choi, Jung Ho Kim
Yeungnam Univ J Med. 2019;36(3):260-264.   Published online June 13, 2019
DOI: https://doi.org/10.12701/yujm.2019.00241
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AbstractAbstract PDF
Pectus excavatum (PE) is known as one of the most common congenital deformities of the anterior chest wall. The Nuss procedure is an effective surgical therapy to correct PE. Here, we report a case of recurrent cardiac tamponade due to hemopericardium that occurred after 16 months following the Nuss procedure. The cause of recurrent hemopericardium was thought to be local, repetitive irritation of the pericardium by the Nuss steel bar. We should keep in mind that this serious complication can occur after the Nuss procedure, even in the late phase.
Early Stage Loeffler's Endocarditis Detected by Transthoracic Echocardiography.
Min Kyu Kang, Won Jong Park, Sung Yun Jung, Su Mi Kim, Tae Hun Kwon, Young Ha Ryu, Jang Won Son, Dong Gu Shin
Yeungnam Univ J Med. 2012;29(2):118-120.   Published online December 31, 2012
DOI: https://doi.org/10.12701/yujm.2012.29.2.118
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AbstractAbstract PDF
Loeffler's endocarditis involves progressive eosinophilic infiltration of the endocardium, which leads to apical thrombotic obliteration of the ventricle and endomyocardial fibrosis, that may finally represent a characteristic feature of restrictive cardiomyopathy. This paper presents a case of a 44-year-old male with symptoms of dyspnea and peripheral hypereosinophilia, who was diagnosed with early stage Loeffler's endocarditis via multicardiac imaging modalities.
The Role of Dynamic CT for the Differential Diagnosis of Solitary Pulmonary Nodule.
Jin Hong Chung, Won Jong Park, Ihn Ho Cho
Yeungnam Univ J Med. 2008;25(2):102-107.   Published online December 31, 2008
DOI: https://doi.org/10.12701/yujm.2008.25.2.102
  • 1,447 View
  • 1 Download
AbstractAbstract PDF
BACKGROUND
Malignant pulmonary nodules account for 30 to 40 percent of all solitary pulmonary nodules (SPNs). Therefore, characterization of SPNs is very important for treatment. Recently, dynamic CT has been widely used for tissue characterization and formation of differential diagnoses. The purpose of this study was to evaluate the ability of dynamic CT to formulate the differential diagnosis of SPNs. MATERIALS AND METHODS: Nineteen patients with SPNs underwent dynamic CT (unenhanced scans, followed by a series of images at 20, 40, 60, 80, 100, 120, 140, 160, and 180 sec after intravenous injection of contrast medium). Diagnosis of SPN was performed based on pathologic findings in needle biopsy samples. Peak enhancement, net enhancement, slope of enhancement, and maximum relative enhancement ratio of the SPN were measured on dynamic CT, and Levene's test was performed to assess benignancy and malignancy. RESULTS: Twelve SPNs were confirmed to have malignant pathology. There were no significant differences between benign and malignant nodules with respect to peak enhancement (p=0.787), net enhancement (p=0.135), or slope of enhancement (p=0.698). The maximal enhancement ratio was increased in malignancy compared to benignancy, but the difference was not statistically significant (p=0.094). CONCLUSION: In our study, the hemodynamic characteristics of dynamic CT were not significantly different between benign and malignant nodules. Therefore, long-term studies of larger patient samples are required to confirm our findings.
A Case of Varicella Pneumonia Associated with Chickenpox in Immunocompetent Patient.
Won Jong Park, Sung Ken Yu, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
Yeungnam Univ J Med. 2007;24(2):339-343.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2.339
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AbstractAbstract PDF
Varicella is a contagious infection in childhood disease typically affecting children aged 2-8 years and usually follows benign outcome. In the adult, clinical presentation is more severe and more commonly associated with complications. Varicella pneumonia, although rare, is a potentially life-threatening complication that should be suspected in any adult with varicella and respiratory symptoms. We report a case of varicella pneumonia in immunocompetent patient. The characteristic radiographic findings consisted of diffuse scattered coarse nodular infiltrations, less than 1cm sized, with ground glass opacity and consolidation in both lung fields. The patients was started on intravenous acyclovir. The chest radiograph performed 2 weeks later showed complete resolution of the pulmonary lesions.
A Case of Glycogen Storage Disease with Hypertrophic Cardiomyopathy.
Dong Hee Kim, Sang Wook Kang, Won Jong Park, Kyoung Ae Jang, Joon Hyuk Choi, Woong Kim, Sang Hee LEE, Geu Ru Hong
Yeungnam Univ J Med. 2006;23(2):252-257.   Published online December 31, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.2.252
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AbstractAbstract PDF
Glycogen storage diseases are a heterogeneous group of metabolic disorder affecting multiple organ system: liver, skeletal muscle, heart and brain. Clinical features include: short status, hepatomegaly, hypoglycemia, dyslipidemia and rare involvement of the myocardium except in the case of type III, glycogen storage diseases with hypertrophic cardiomyopathy in adult, which is extremely rare. We treated a case of hypertrophic cardiomyopathy with hepatomegaly that was unknown etiology. The patient was diagnosed as having glycogen storage disease. This 46-year old women was transferred with dyspnea on exertion and abnormal LFTs. She was diagnosed with hypertrophic cardiomyopathy by echocardiography but there was no specific cause for hypertrophic cardiomyopathy. A liver biopsy was performed. The result showed glycogen storage disease possible type III, IV or IX. In conclusion, patients with hypertrophic cardiomyopathy of unknown etiology and abnormal LFTs should be evaluated for glycogen storage disease.
A Case of Gefitinib (Iressa(R))-associated Tumor Lysis Syndrome in Adenocarcinoma of the Lung.
Kyu Jin Kim, Won Jong Park, Sung Ken Yu, Kyeong Cheol Shin, Jin Hong Chung, Myung Soo Hyun, Kwan Ho Lee
Yeungnam Univ J Med. 2006;23(2):221-226.   Published online December 31, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.2.221
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AbstractAbstract PDF
The tumor lysis syndrome has been described as biochemical disturbances associated with rapid destruction of tumor cells and subsequent synchronized massive release of cellular breakdown products sufficient to overwhelm excretory mechanisms and the body's normal reutilization capacity. The cardinal signs of the tumor lysis syndrome are hyperkalemia, hyperphosphatemia, hypocalcemia and hyperuricemia. Gefitinib (Iressa) is an oral, selective epidermal growth factor receptor (EGFR) inhibitor that has activity in female, non-smoker and non-small cell lung cancer with an EGFR mutation. Gefitinib is a well tolerated drug with few side effects. It has been associated with skin rash, diarrhea, nausea, a decrease in liver function and interstitial lung disease. However, there is no prior report of the tumor lysis syndrome associated with gefitinib. We report a case of a 54 year-old woman who developed tumor lysis syndrome that might have been induced by gefitinib after the treatment of adenocarcinoma of lung with an EGFR mutation.
The Usefulness of Integrated PET/CT to Distinguish between Benignancy and Malignancy in Solitary Pulmonary Nodule.
Won Jong Park, Dong Hee Kim, Sung Ken Yu, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee, Kyung Ah Chun, Ihn Ho Cho
Yeungnam Univ J Med. 2006;23(2):205-212.   Published online December 31, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.2.205
  • 1,508 View
  • 1 Download
AbstractAbstract PDF
BACKGROUND
Malignant pulmonary nodules account for about 30 to 40 percent of solitary pulmonary nodules (SPN). Therefore, tissue characterization of SPNs is very important. Recently, PET/CT has been widely used for tissue characterization, and has become of importance. The purpose of this study was to compare and to assess multiple factors in PET/CT comparing benign and malignant nodules. MATERIALS AND METHOD: Nineteen patients with SPN underwent PET/CT and biopsy. The difference of standardized uptake value 1 (SUV1), standardized uptake value 2 (SUV2) and retention index in PET/CT between malignancy and benignancy were compared by Levene's test. RESULT: There were twelve malignant and seven benign nodules. SUV1 and SUV2 were significantly different between malignant nodule and benign nodule (p=0.006 and 0.022), but retention index was not significantly different between malignant nodule and benign nodule (p=0.526). By receiver-operating-characteristic (ROC) analysis, the sensitivity was 66.7% and the specificity was 71.4% at a cut off value of 5.40 in SUV1. The sensitivity was 75% and the specificity was 71.4% at cut off value of 7.45 in SUV2. CONCLUSION: There was a statistically significant difference in SUV1 and SUV2 between benign and malignant nodules. However, the cut off value of SUV1 and SUV2 by receiver-operating-characteristic (ROC) analysis was 5.40 and 7.45 which is different from previous studies. Therefore, studies on a larger sample of patients are required for confirmation.
A Case of Amiodarone-induced Interstitial Lung Disease
Byeong Hun Kim, Won Jong Park, Jin Hong Chung, Kwan Ho Lee, Young Jo Kim, Bong Sup Shim, Hyun Woo Lee
Yeungnam Univ J Med. 1994;11(1):186-192.   Published online June 30, 1994
DOI: https://doi.org/10.12701/yujm.1994.11.1.186
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AbstractAbstract PDF
Amiodarone has a potent suppressive effect on supraventricular and ventricular dysrhythmias, so has widely used as a class III antiarrhythmic agent. However, significant side effects were noted in over 50% of patients treated. Pulmonary toxicity represents the most serious adverse reaction limiting the clinical efficacy of this new antidysrhythmic drug. A 66-year-old male had received amiodarone 200 mg/day for 7 months to control high grade ventricular premature contraction and was admitted due to dyspnea on exertion for 1 week. At the time of admission end-inspiratory crepitant rale was heard on auscultation. The roentgenogram of his chest revealed reticular and granular radiopaque densities on both lower lung fields and high resonance CT revealed interstitial fibrosis and pneumonic consolidations on the periphery of the both middle and lower lobes. Trans-bronchoscopic lung biopsy revealed non-specific interstitial fibrosis. The laboratory findings were non-specific. We present a case of amiodarone-induced interstitial pulmonary disease clinically improved by corticosteroid therapy
A Study on the Serologic Parameters in Petients with Anemia of Chronic Renal Failure-According to Erythropoietin Treatment
Jong Sik Lim, Ho Jung Kang, Won Jong Park, Jun Young Do, Kyeung Woo Yun
Yeungnam Univ J Med. 1994;11(1):82-93.   Published online June 30, 1994
DOI: https://doi.org/10.12701/yujm.1994.11.1.82
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AbstractAbstract PDF
Clinical study was carried out on the 64 hemodialysis patients (HD) with chronic renal failure who had been treated from December 1992 to July 1993 in Yeungnam University Hospital. The following results were obtained. In hematologic parameters, MCH was 28.8±2.0 pg, and MCV was 92.4±4.7 fl. Result revealed normochromic and normocytic anemia. Mean values of serum ferritin were 657.4±292.0 ng/ml in men and 511.5±370 g in women. Mean values of serum iron were 145.5±63.7 µg/dl. Mean values of transferrin saturation was 61.6±28.4%. Serum ferritin, serum iron and transferrin saturation were higher in HD group than normal reference. In erythropoietin treatment group, Hb and Hct were significantly higher than non-erythropoietin treatment group. Amount of transfusion was significantly higher in non-erythropoietin treatment group than erythropoietin treatment group (p<0.05). Values of iron, transferrin saturation were significantly higher in abnormal liver function test (LFT0 hemodialysis group than normal LFT group (p<0.05). Transfusion amounts revealed positive correlation with ferritin (r=0.4675), transferrin saturation (r=0.3823) and iron (r=0.3386) (p<0.05). In conclusion, erythropoietin treatment can reduce requirement of blood transfusion and transfusion related side effects such as iron overload, hemosiderosis and hemochromatosis.

JYMS : Journal of Yeungnam Medical Science