- Lactate: a multifunctional signaling molecule
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Tae-Yoon Lee
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Yeungnam Univ J Med. 2021;38(3):183-193. Published online February 18, 2021
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DOI: https://doi.org/10.12701/yujm.2020.00892
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Abstract
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- Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.
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Zan Li, Qiuxue Wu, Zhenzhen Wei, Yuli Zhang, Bin Han, Sailei Jia, Hua Sui, Qingfeng Tang Pharmacological Research - Modern Chinese Medicine.2024; 10: 100347. CrossRef - The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis
Philipp Terpe, Stefanie Ruhs, Virginie Dubourg, Michael Bucher, Michael Gekle Journal of Biomedical Science.2024;[Epub] CrossRef - Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation
Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McC Molecular Metabolism.2024; 81: 101888. CrossRef - Association of prehospital lactate levels with base excess in various emergencies – a retrospective study
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Simon Höving, Stefanie Dörr, Marc Akermann, Arthur Schiller, Kristina Lorenz, Daniel Schwendemann, Joachim Franzke, Sebastian Brandt 3D Printing and Additive Manufacturing.2024;[Epub] CrossRef - A novel approach using copper oxide nanocomposites-based biosensor for lactate detection in athletes
Chunming Li, Mingyue Zhang, Chengruo Huang Alexandria Engineering Journal.2024; 105: 218. CrossRef - Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y)
Precious C. Obiako, Solomon O. Ayisire, Christie M. Sayes Environment International.2024; 190: 108864. CrossRef - Association between the oral microbiome and brain resting state connectivity in schizophrenia
Dongdong Lin, Zening Fu, Jingyu Liu, Nora Perrone-Bizzozero, Kent E. Hutchison, Juan Bustillo, Yuhui Du, Godfrey Pearlson, Vince D. Calhoun Schizophrenia Research.2024; 270: 392. CrossRef - The Multiple Roles of Lactate in the Skeletal Muscle
Bianca Bartoloni, Michele Mannelli, Tania Gamberi, Tania Fiaschi Cells.2024; 13(14): 1177. CrossRef - Anaerobic Glycolysis and Ischemic Stroke: From Mechanisms and Signaling Pathways to Natural Product Therapy
Jia Pu, Jin Han, Jiehong Yang, Li Yu, Haitong Wan ACS Chemical Neuroscience.2024; 15(17): 3090. CrossRef - Lactic acid: The culprit behind the immunosuppressive microenvironment in hepatocellular carcinoma
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Tao Zhang, Linjian Chen, Gatkek Kueth, Emily Shao, Xiaohui Wang, Tuanzhu Ha, David L. Williams, Chuanfu Li, Min Fan, Kun Yang Frontiers in Immunology.2024;[Epub] CrossRef - Utility of Lactate Levels in the Diagnosis and Prognosis of Septic Shock
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Kevin Li, Maria Romero, Macarena Cañardo, Denisse Garcia, Alain Diaz, Bonnie B. Blomberg, Daniela Frasca Mechanisms of Ageing and Development.2023; 209: 111742. CrossRef - The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng Genes & Diseases.2023; 10(5): 2029. CrossRef - Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
Yue Wu, Wanqi Ma, Wei Liu, Shuping Zhang Cell Biology International.2023; 47(2): 295. CrossRef - Insights on the role of l-lactate as a signaling molecule in skin aging
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Dalia Barayan, Fadi Khalaf, Carly M. Knuth, Abdikarim Abdullahi, Sarah Rehou, Robert A. Screaton, Marc G. Jeschke American Journal of Physiology-Endocrinology and Metabolism.2023; 325(4): E423. CrossRef - Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure
Yong Lin, Gengjie Yan, Minggang Wang, Kan Zhang, Faming Shu, Meiyan Liu, Fuli Long, Dewen Mao Open Life Sciences.2023;[Epub] CrossRef - Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
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Oleg Shuvalov, Yulia Kirdeeva, Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Hans-Uwe Simon, Nickolai A. Barlev Antioxidants.2023; 12(11): 2012. CrossRef - Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis
Chuan Cheng, Zhiqiang Xu, Cao Yang, Xinghuo Wu Medical Hypotheses.2022; 159: 110758. CrossRef - A bioorthogonal chemical reporter for the detection and identification of protein lactylation
Yanan Sun, Yanchi Chen, Tao Peng Chemical Science.2022; 13(20): 6019. CrossRef - Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu Pharmacological Research.2022; 181: 106270. CrossRef - Understanding lactate sensing and signalling
Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro Trends in Endocrinology & Metabolism.2022; 33(10): 722. CrossRef - Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype
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Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna EMBO reports.2022;[Epub] CrossRef - Crosstalk between glucose metabolism, lactate production and immune response modulation
Lei Ye, Yi Jiang, Mingming Zhang Cytokine & Growth Factor Reviews.2022; 68: 81. CrossRef - Metabolic orchestration of the wound healing response
Sabine A. Eming, Peter J. Murray, Edward J. Pearce Cell Metabolism.2021; 33(9): 1726. CrossRef - Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer
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- Platelet Activating Factor-Acetylhydrolase
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Tae-Yoon Lee
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Yeungnam Univ J Med. 2007;24(2 Suppl):S142-151. Published online December 31, 2007
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DOI: https://doi.org/10.12701/yujm.2007.24.2S.S142
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Abstract
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- Platelet activating factor (PAF) is a phospholipid with a strong inflammatory mediator. PAF is synthesized in a variety of cells in response to inflammatory stimuli. PAF is degraded by intracellular and extracellular PAF-acetylhydrolases (PAF-AHs) thus providing proper level of PAF. Plasma PAF-AH deficiency is associated with several diseases such as asthma, systemic lupus erythematosus, juvenile rheumatoid arthritis, acute myocardial infarction, diabetes, and membranous nephropathy. Cloning of plasma PAF-AH gene enabled the use of recombinant PAF-AH as a therapeutic tool for these PAF-mediated diseases.
- Comparison of REP13E12 PCR with Amplicor MTB for the Detection of Mycobacterium tuberculosis in Respiratory Specimens
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Tae-Yoon Lee
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Yeungnam Univ J Med. 2007;24(2 Suppl):S456-462. Published online December 31, 2007
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DOI: https://doi.org/10.12701/yujm.2007.24.2S.S456
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Abstract
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- Background
s:In recent years, the incidence of tuberculosis has increased mainly in high-risk populations. Classical laboratory diagnostic methods for tuberculosis have low sensitivity and time consuming procedures. Thus, it is important to identify the presence of Mycobacterium tuberculosis in the clinical specimens earlier than the culture results for the decision to initiate anti-tuberculosis therapy. Lee et al. reported a species-specific repeated sequence from a Korean M. tuberculosis isolate, which was later proved to be a part of REP13E12 repetitive sequence.
Materials and Methods:In this study, we compared the acid-fast staining, culture, Amplicor MTB (Roche), and REP13E12 PCR for detection of M. tuberculosis using 88 clinical samples. The sensitivity, specificity, positive and negative predictive values were compared.
Results :REP13E12 PCR showed equivalent score to Amplicor MTB. Both PCR-based methods showed better score than conventional stain and culture methods.
Conclusion :This result suggested that REP13E12 PCR is helpful for the rapid detection of the M. tuberculosis from clinical specimens.
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