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Tae-Yoon Lee 3 Articles
Lactate: a multifunctional signaling molecule
Tae-Yoon Lee
Yeungnam Univ J Med. 2021;38(3):183-193.   Published online February 18, 2021
DOI: https://doi.org/10.12701/yujm.2020.00892
  • 17,812 View
  • 463 Download
  • 29 Citations
AbstractAbstract PDF
Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.

Citations

Citations to this article as recorded by  
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    Mechanisms of Ageing and Development.2023; 209: 111742.     CrossRef
  • The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
    Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng
    Genes & Diseases.2023; 10(5): 2029.     CrossRef
  • Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
    Yue Wu, Wanqi Ma, Wei Liu, Shuping Zhang
    Cell Biology International.2023; 47(2): 295.     CrossRef
  • Insights on the role of l-lactate as a signaling molecule in skin aging
    Salvatore Chirumbolo, Dario Bertossi, Pierre Magistretti
    Biogerontology.2023; 24(5): 709.     CrossRef
  • Role of L-lactate as an energy substrate in primary rat podocytes under physiological and glucose deprivation conditions
    Maria Szrejder, Marlena Typiak, Piotr Pikul, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Magdalena Narajczyk, Agnieszka Piwkowska
    European Journal of Cell Biology.2023; 102(2): 151298.     CrossRef
  • Utilization of delactosed whey permeate for the synthesis of ethyl acetate with Kluyveromyces marxianus
    Andreas Hoffmann, Alexander Franz, Thomas Walther, Christian Löser
    Applied Microbiology and Biotechnology.2023; 107(5-6): 1635.     CrossRef
  • Lactate, histone lactylation and cancer hallmarks
    Xinyu Lv, Yingying Lv, Xiaofeng Dai
    Expert Reviews in Molecular Medicine.2023;[Epub]     CrossRef
  • Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
    Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
    Aging.2023;[Epub]     CrossRef
  • Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
    Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Shilpa.N. Thumbooru, Madhukiran Parvathaneni, Veera Venkata Satyanarayana Reddy Karri
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  • Immunomodulatory Properties of Probiotics and Their Derived Bioactive Compounds
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    BioTech.2023; 12(2): 38.     CrossRef
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    Lairong Wang, Yan Wang, Meijuan Meng, Nana Ma, Guozhen Wei, Ran Huo, Guangjun Chang, Xiangzhen Shen
    Microbial Pathogenesis.2023; 180: 106135.     CrossRef
  • ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation
    Seung-Hwa Woo, Yun Jeong Mo, Yun-Il Lee, Ji Hwan Park, Daehee Hwang, Tae Jun Park, Hee Young Kang, Sang Chul Park, Young-Sam Lee
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    Marylène Bertrand, Frédéric Szeremeta, Nadège Hervouet‐Coste, Vincent Sarou‐Kanian, Céline Landon, Séverine Morisset‐Lopez, Martine Decoville
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  • Reply to Lund et al.
    Dalia Barayan, Fadi Khalaf, Carly M. Knuth, Abdikarim Abdullahi, Sarah Rehou, Robert A. Screaton, Marc G. Jeschke
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  • Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure
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  • Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
    Nataliya A. Kolotyeva, Frida N. Gilmiyarova, Anton S. Averchuk, Tatiana I. Baranich, Nataliya A. Rozanova, Maria V. Kukla, Pavel P. Tregub, Alla B. Salmina
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  • Phytochemicals Target Multiple Metabolic Pathways in Cancer
    Oleg Shuvalov, Yulia Kirdeeva, Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Hans-Uwe Simon, Nickolai A. Barlev
    Antioxidants.2023; 12(11): 2012.     CrossRef
  • Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis
    Chuan Cheng, Zhiqiang Xu, Cao Yang, Xinghuo Wu
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    Chemical Science.2022; 13(20): 6019.     CrossRef
  • Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
    Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu
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  • Understanding lactate sensing and signalling
    Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro
    Trends in Endocrinology & Metabolism.2022; 33(10): 722.     CrossRef
  • Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype
    Oscar Fraile-Martinez, Cielo García-Montero, Miguel Ángel Alvarez-Mon, Ana M. Gomez-Lahoz, Jorge Monserrat, Maria Llavero-Valero, Fernando Ruiz-Grande, Santiago Coca, Melchor Alvarez-Mon, Julia Buján, Natalio García-Honduvilla, Jose V. Saz, Miguel A. Orte
    Journal of Personalized Medicine.2022; 12(10): 1642.     CrossRef
  • Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
    Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna
    EMBO reports.2022;[Epub]     CrossRef
  • Crosstalk between glucose metabolism, lactate production and immune response modulation
    Lei Ye, Yi Jiang, Mingming Zhang
    Cytokine & Growth Factor Reviews.2022; 68: 81.     CrossRef
  • Metabolic orchestration of the wound healing response
    Sabine A. Eming, Peter J. Murray, Edward J. Pearce
    Cell Metabolism.2021; 33(9): 1726.     CrossRef
  • Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer
    Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, Kelly McCann, Leonie Voorwerk, Javier I. J. Orozco, Miquel Ensenyat-Mendez, Borja Sesé, Maggie L. DiNome, Diego M. Marzese
    Cancers.2021; 13(16): 4139.     CrossRef
Platelet Activating Factor-Acetylhydrolase
Tae-Yoon Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S142-151.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S142
  • 1,028 View
  • 4 Download
AbstractAbstract PDF
Platelet activating factor (PAF) is a phospholipid with a strong inflammatory mediator. PAF is synthesized in a variety of cells in response to inflammatory stimuli. PAF is degraded by intracellular and extracellular PAF-acetylhydrolases (PAF-AHs) thus providing proper level of PAF. Plasma PAF-AH deficiency is associated with several diseases such as asthma, systemic lupus erythematosus, juvenile rheumatoid arthritis, acute myocardial infarction, diabetes, and membranous nephropathy. Cloning of plasma PAF-AH gene enabled the use of recombinant PAF-AH as a therapeutic tool for these PAF-mediated diseases.
Comparison of REP13E12 PCR with Amplicor MTB for the Detection of Mycobacterium tuberculosis in Respiratory Specimens
Tae-Yoon Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S456-462.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S456
  • 1,034 View
  • 2 Download
AbstractAbstract PDF
Background
s:In recent years, the incidence of tuberculosis has increased mainly in high-risk populations. Classical laboratory diagnostic methods for tuberculosis have low sensitivity and time consuming procedures. Thus, it is important to identify the presence of Mycobacterium tuberculosis in the clinical specimens earlier than the culture results for the decision to initiate anti-tuberculosis therapy. Lee et al. reported a species-specific repeated sequence from a Korean M. tuberculosis isolate, which was later proved to be a part of REP13E12 repetitive sequence. Materials and Methods:In this study, we compared the acid-fast staining, culture, Amplicor MTB (Roche), and REP13E12 PCR for detection of M. tuberculosis using 88 clinical samples. The sensitivity, specificity, positive and negative predictive values were compared.
Results
:REP13E12 PCR showed equivalent score to Amplicor MTB. Both PCR-based methods showed better score than conventional stain and culture methods.
Conclusion
:This result suggested that REP13E12 PCR is helpful for the rapid detection of the M. tuberculosis from clinical specimens.

JYMS : Journal of Yeungnam Medical Science