Skip Navigation
Skip to contents

JYMS : Journal of Yeungnam Medical Science

Indexed in: ESCI, Scopus, PubMed,
PubMed Central, CAS, DOAJ, KCI
FREE article processing charge
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Soo Min Son 1 Article
The Effects of Ethanol on Cholinesterase Inactivation by Organophosphorous.
Hyoung Chul Choi, Jong Ho Kim, Jeoung Hee Ha, Kwang Yoon Lee, Won Joon Kim, Hyun Jae Woo, Chang Uk Huh, Soo Min Son, Eun Jin Chun
Yeungnam Univ J Med. 1999;16(2):326-332.   Published online December 31, 1999
DOI: https://doi.org/10.12701/yujm.1999.16.2.326
  • 1,442 View
  • 1 Download
AbstractAbstract PDF
BACKGROUND
In korea the agricultural community widely uses organophosphorous, and organophosphorous poisonings are increasing every year. We compared change in activity of acetylcholinesterase and pseudocholinesterase by organophosphorous and by the interaction of ethanol and organophosphorous. We also compared the effect of reversible anticholinesterase drugs, physostigmine and neostigmine. The object of this study is to investigate the effects of several anticholinesterase drugs and on how ethanol influences the activity of cholinesterase. MATERIALS AND METHODS: Fifteen male university students were randomly selected, and blood samples were taken from the antecubital vein. The acetylcholinesterase in the RBC and the pseudocholinesterase in the serum were extracted and separated. The enzyme activity change was measured by the electrometric method. After adding acetylcholine, the pH change was measured with a pH meter. RESULTS AND CONCLUSION: Our results indicated that reversible anticholinesterase drugs decreased the cholinesterase activity more efficiently than organophosphorous. The acetyl cholinesterase and pseudocholinosterase activity were decreased by ethanol. When ethanol was added, oxime a cholinesterase activator, increased acetylcholinesterase activity but dose not increased pseudocholinesterase activity.

JYMS : Journal of Yeungnam Medical Science