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JYMS : Journal of Yeungnam Medical Science

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Sol Hee Park 1 Article
Effect of preoperative pregabalin on postoperative pain after gastrectomy
Chan Yoon Park, Sol Hee Park, Dong Gun Lim, Eun Kyung Choi
Yeungnam Univ J Med. 2018;35(1):40-44.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.40
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  • 2 Crossref
AbstractAbstract PDF
Background
Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain.
Methods
Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period.
Results
The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth.
Conclusion
A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.

Citations

Citations to this article as recorded by  
  • Treatment of acute postoperative pain in patients undergoing open abdominal aortic repair (current state of the problem)
    Anzhelika V. Kozhanova, Georgy P. Plotnikov
    Regional Anesthesia and Acute Pain Management.2022; 16(1): 45.     CrossRef
  • Comparison of premedication with 75 mg and 150 mg pregabalin for postoperative analgesia in total hysterectomy patients - A randomised control trial
    Ajish Varghese Cheruvathur, Dilshad Thondi Parambil, Saurabh Vig, Salman Mohammed Kutty Chenath, Priyadharshini Nagaraj, Krupa Mulgaonkar, S Jeevithan
    Indian Journal of Clinical Anaesthesia.2022; 9(4): 467.     CrossRef

JYMS : Journal of Yeungnam Medical Science