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JYMS : Journal of Yeungnam Medical Science

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Hee Yeon Kim 1 Article
Tumor lysis syndrome following sorafenib treatment in hepatocellular carcinoma.
Shin Young Kim, Hee Yeon Kim, Yu Seung Kim, Sang Min Lee, Chang Wook Kim
Yeungnam Univ J Med. 2015;32(1):47-49.   Published online June 30, 2015
DOI: https://doi.org/10.12701/yujm.2015.32.1.47
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AbstractAbstract PDF
Sorafenib is indicated for the treatment of advanced hepatocellular carcinoma (HCC), but although rare, tumor lysis syndrome (TLS) can be fatal in HCC patients with a large tumor burden. The authors describe the case of a 55-year-old hepatitis B carrier who visited our clinic with progressive dyspnea for 3 weeks. Chest and abdominal computed tomography revealed a huge HCC in the left lobe of the liver with invasion of the inferior vena cava, right atrium, and pulmonary arteries. After 8 days of sorafenib administration, TLS was diagnosed based on the characteristic findings of hyperuricemia, hyperkalemia, and acute kidney injury with massive tumor necrosis by follow-up imaging. Despite discontinuation of sorafenib and supportive care, the patient's clinical course rapidly deteriorated. The authors describe a rare but fatal complication that occurred soon after sorafenib initiation for HCC. Careful follow-up is required after commencing sorafenib therapy for the early diagnosis and management of TLS.

Citations

Citations to this article as recorded by  
  • A case of hepatocellular carcinoma caused severe tumor lysis by ramucirumab
    Yuhi Sakamoto, Keizo Kato, Hiroshi Abe, Takeshi Yonezawa, Sadahiro Ito, Makiko Ika, Kiichiro Yoza, Mamika Ohara, Shogo Sakasai, Shohei Shimizu, Shinji Endo
    Kanzo.2021; 62(3): 129.     CrossRef
  • Sorafenib-induced tumor lysis syndrome in a patient with metastatic hepatocellular carcinoma
    Sardar Zakariya Imam, Mohammad Faizan Zahid, Muhammad Asad Maqbool
    Hematology/Oncology and Stem Cell Therapy.2020; 13(3): 168.     CrossRef

JYMS : Journal of Yeungnam Medical Science