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JYMS : Journal of Yeungnam Medical Science

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Hee Sun Cho 1 Article
A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine.
Yong Gil Kim, Sang Jin Lee, Min Kyung Kim, Kyung Hee Lee, Myung Soo Hyun, Hee Sun Cho
Yeungnam Univ J Med. 2004;21(2):237-241.   Published online December 31, 2004
DOI: https://doi.org/10.12701/yujm.2004.21.2.237
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Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia (3300/microliter with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5 (-), CD10 (-), CD19 (+), CD25 (+), CD103 (+), CD20 (+), lambda (+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.

JYMS : Journal of Yeungnam Medical Science