Journal of Yeungnam Medical Science

Haneol Ko

1 Article

Anatomy
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review: Haneol Ko, Sang-Pil Yoon; J Yeungnam Med Sci. 2022;39(4):269-277. Published online February 14, 2022; DOI: https://doi.org/10.12701/jyms.2021.01683

9,726 View
141 Download
7 Web of Science
7 Crossref

The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

Citations

Citations to this article as recorded by

Application of Optogenetic Neuromodulation in Regulating Depression
Jin Zhang, Xiang Peng, Man Li, Xiao-ming Zhang, Hong-chun Xiang
Current Medical Science.2025; 45(2): 185. CrossRef
Modulating Proteasome Function with Polyphenol Metabolites: A Promising Therapeutic Avenue for Alzheimer's Disease
Nyerovwo Charity Okei
European Journal of Medical and Health Research.2024; 2(2): 16. CrossRef
A comprehensive review of optical fiber technologies in optogenetics and their prospective developments in future clinical therapies
Siyu Chen, Zhuo Wang, Kun Xiao, Benzhao He, Jing Zhao, Xin Yang, Qingqing Liu, Anuj K. Sharma, Arnaldo Leal Junior, Rui Min
Optics & Laser Technology.2024; 179: 111332. CrossRef
Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders
Salman Alfihed, Majed Majrashi, Muhammad Ansary, Naif Alshamrani, Shahad H. Albrahim, Abdulrahman Alsolami, Hala A. Alamari, Adnan Zaman, Dhaifallah Almutairi, Abdulaziz Kurdi, Mai M. Alzaydi, Thamer Tabbakh, Faisal Al-Otaibi
Biosensors.2024; 14(7): 335. CrossRef
Daily Dynamics of Resting-State Electroencephalographic Theta and Gamma Fluctuations Are Associated With Cognitive Performance in Healthy Aging
Kenza Bennis, Francis Eustache, Fabienne Collette, Gilles Vandewalle, Thomas Hinault, Gali Weissberger
The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.2024;[Epub] CrossRef
Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu
Scientific Reports.2023;[Epub] CrossRef
Light-Controlled Modulation and Analysis of Neuronal Functions
Carlo Matera, Piotr Bregestovski
International Journal of Molecular Sciences.2022; 23(21): 12921. CrossRef

Author index